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Both the kK and kK mediated ubiquitination leads
2021-06-09
Both, the kK3 and kK5-mediated ubiquitination leads to rapid internalisation of target proteins followed by lysosomal degradation, similar to that seen for MARCH-1/8 [77]. Ubiquitination activity of kK3 and kK5 depends on the positioning of the targeted lysine (or cysteine) residues [22]. The positi
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Like all other cellular processes ubiquitination
2021-06-09
Like all other cellular processes, ubiquitination is also tightly regulated; more so, as myriads of pathways are controlled via this conjugation and dysregulation of ubiquitination has been implicated in various diseases including cancer [16], [17]. Quite a few of such regulatory mechanisms that con
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In conclusion our results demonstrate that CCLP promoted ost
2021-06-09
In conclusion, our results demonstrate that CCLP promoted osteoblast proliferation, differentiation, and mineralization via activation of ERK, p38, and Smad1/5/8 (Fig. 9). The residues of the GGKQNVGFGP-sequence in CCLP showed the highest significant binding relationship with the target activin rece
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Protein degradation via UPP involves two steps One
2021-06-09
Protein degradation via UPP involves two steps. One step is the conjugation of multiple ubiquitin to a substrate. The other step is the degradation of tagged protein by the downstream 26S proteasome complex. Protein ubiquitination is the E1–E2–E3 enzymatic cascade (Hershko & Ciechanover, 1998). E1-a
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One of the hallmarks of the terminal stages
2021-06-09
One of the hallmarks of the terminal stages of apoptosis is the fragmentation of chromosomal DNA that proceeds in a two-step manner: the DNA is initially cleaved into 50–300kb fragments and eventually into oligonucleosomal pieces [12], [13]. The two major apoptotic nucleases are DNA fragmentation fa
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We also discovered important clues
2021-06-09
We also discovered important clues to domain Carboplatin of DGKs and how to exploit these regions for development of DGKα-selective inhibitors. The identification of a probe-modified site at the C1 domain provided the first evidence of a ligand binding site remote from the ATP binding region of DGKs
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synthase br Application of the screening system for ITP bind
2021-06-09
Application of the screening system for ITP-binding proteins Inosine is a nucleoside with hypoxanthine as a base. Inosine nucleotides are relatively abundant in human synthase because inosine monophosphate (IMP) is a general precursor molecule for the de novo synthesis of AMP and GMP or a produc
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br Contributors br Acknowledgements br
2021-06-09
Contributors Acknowledgements Introduction Pemphigus disorders are characterized by autoantibodies binding to desmosomes between epidermal cells, resulting in the loss of cell to cell adhesion and blister formation. In pemphigus foliaceus, autoantibodies predominantly bind to desmoglein 1,
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Henderson et al reported that allergen induced airway remode
2021-06-09
Henderson et al. [20] reported that allergen-induced airway remodeling was blocked by the CysLT1 receptor antagonist montelukast. The development of epithelial thickening and mucus accumulation at relatively small sitagliptin phosphate receptor was also suppressed by montelukast. The CysLT2 recepto
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br Materials and methods br Results br
2021-06-09
Materials and methods Results Discussion In the present study, as a trial to evaluate the marine ciliate E. crassus for further studies, its susceptibilities to B[a]P and β-NF were measured. Acute toxicity of B[a]P in aquatic organisms has been extensively studied, but not enough data is av
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We have previously disclosed the
2021-06-09
We have previously disclosed the discovery of a 7-azaindole-3-acetic Busulfan synthesis CRTh2 antagonist chemotype 1 from HTS and its subsequent optimization to give 2 as a potent and orally bioavailable inhibitor of eosinophil shape change (SC) in human whole blood. Subsequent to disclosure of tha
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Compound was generated using a literature procedure
2021-06-09
Compound was generated using a literature procedure and required two-step Dess–Martin-periodinane/Pinnick oxidation prior to the methylation of the sulfonamide. Compound () was obtained from the Suzuki coupling of the methyl ester intermediate (en route to SBE 13 HCl ). Hydrolysis of all methyl este
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Apart from neutrophil mediated inflammation the production o
2021-06-09
Apart from neutrophil-mediated inflammation, the production of pro-inflammatory cytokines and chemokines from PGD2/CRTH2 activated macrophages could further aggravate LPS-induced lung injury (Eguchi et al., 2011; Jandl et al., 2016). Interestingly, genetic ablation of CRTH2 diminishes the TNF-α prod
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Regarding the effects of CRF on anxiety Sahuque et al
2021-06-09
Regarding the effects of CRF on anxiety, Sahuque et al. (2006) have demonstrated that this neuropeptide also enhances anxiety when injected into the bed nucleus of the stria terminalis (BNST), a Cy7 carboxylic acid (non-sulfonated) structure that has also been related to defensive behavior (Casada
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br Next let s recall some
2021-06-09
Next, let's recall some definitions and notations from [14] which are necessary to obtain the proof of Theorem 1. Let denote the CMV matrix whose Verblunsky coefficients replaced by , that is The corresponding extended CMV matrix is Recall the definition of in the proof of Theorem 2, replace by
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