• The present study indicates elevated ATX activity

  2025-01-22

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In Cardiotonic steroid to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appea

• In PMCA Mg favors the conversion

  2025-01-22

  

  In PMCA, Mg2+ favors the conversion E1P → E2P [13] and, as in SERCA [11], it accelerates the phosphorylation displacing the E1–E2 equilibrium towards E1. In SERCA, Sørensen et al. [41], proposed that ATP reacts by an associative mechanism mediated by two Mg2+ ions to form an aspartyl-phosphorylated

• Recent studies have demonstrated significant cross talk betw

  2025-01-22

  

  Recent studies have demonstrated significant cross-talk between XRCC1 (a key player in Free fatty acid receptor 1 agonist excision repair (BER) and single strand break repair) and DDR [30], [31], [32]. ATM and DNA-PKcs are known to be involved in the phosphorylation of XRCC1 to promote BER [30], [3

• The class C receptors also share a

  2025-01-22

  

  The class C receptors also share a common agonist-binding mode. In all cases, an agonist induces VFT closure by forming intermolecular bonds with surface residues in both the LB1 and LB2 domains (Geng et al., 2013, Geng et al., 2016, Kunishima et al., 2000, Muto et al., 2007, Nuemket et al., 2017, T

• In the current study SA was assessed to confirm

  2025-01-22

  

  In the current study, SA was assessed to confirm the safety of CS addition to erythrocytes SA as well as SA elicits antioxidant action. It has been reported that, ROS induced desialylation by depletion of SA content from cell surfaces (Pawluczyk et al., 2014, Harisa, 2015). Therefore, significant de

• In addition to calpain I activity

  2025-01-22

  

  In addition to calpain I activity, cathepsin activities have been proven to be linked to apoptotic signaling. Cathepsin B and cathepsin D are two of the most abundant and well-investigated lysosome acid-dependent proteases that are involved in the apoptotic regulation (Ferri & Kroemer, 2001). Cathep

• Echinocandin resistance is systematically associated with po

  2025-01-22

  

  Echinocandin resistance is systematically associated with point mutations in either FSK1 or FSK2 genes [7], [104]. These mutations are located in two different not spot regions of these genes named HS1 and HS2. Hot spot mutations have been reported in C. albicans, C. glabrata, C. tropicalis, C. krus

• Since the first studies of betaine aldehyde

  2025-01-21

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other Mycophenolate Mofetil as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack

• Since the first studies of betaine aldehyde

  2025-01-21

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other Carmustine as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of attention

• Spectroscopic techniques are powerful biophysical tools used

  2025-01-21

  

  Spectroscopic techniques are powerful biophysical tools used in the study of biomolecular structures, including those of proteins. UV–Vis alpha adrenergic blockers spectroscopy makes use of absorption property of the protein peptide backbone at around 218 nm, and aromatic amino acid residues primar

• Human testicular peritubular cells HTPCs are also the only h

  2025-01-21

  

  Human testicular peritubular ML347 (HTPCs) are also the only human testicular cell type that can be isolated, cultured and studied in vitro (Albrecht et al., 2006, Mayerhofer, 2013). Results from recent studies indicate that their roles go beyond sperm transport and include immunological functions.

• br Thymic expression of AChR Both linear unfolded epitopes o

  2025-01-21

  

  Thymic expression of AChR Both linear unfolded epitopes of AChR subunits and the intact AChR are avidly expressed in thymus, particularly by thymic epithelial cells and myoid cells [17], [18], [19]. AChR-antibody positive MG patients often show thymic hyperplasia, characterized by lymphoid follic

• This study was funded and

  2025-01-21

  

  This study was funded and supported by Tehran University of Medical Sciences and Health Services; and Iran National Science Foundation. Introduction The enzyme acetylcholinesterase (AChE) plays a central role in the signal transduction in the nervous system, hydrolyzing the neurotransmitter acet

• Until now five muscarinic receptor M genes

  2025-01-21

  

  Until now, five muscarinic receptor (M1-5) genes have been cloned, but, M1-3 receptors are functionally recognized in the lungs. Smooth muscle contraction is mainly mediated by M3. M2 may also participate in the contraction via Gi protein which leads to a decrease in cAMP. On the other hand, M2 is l

• Search sphere This sphere includes the acetylcholine binding

  2025-01-21

  

  Search sphere 1: This sphere includes the Metabolic enzyme regulator binding site between the α–γ subunits. The center point of the search area was located at x=35.26, y=77.67, z=137.74 and the initial search radius was set to 27Å which assures that the corresponding area outside the channel pore of

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